Hi-5 Rix4446
Order
Species
Common Name(s)
Cabbage looper
Primary Designation
Hi-5 Rix4446
Accession No.
CVCL_RW20
Stage
Tissue
References
Monie, A., Hung, C-F., Roden, R., & Wu, T-C. (2008). CERVARIX: A VACCINE FOR THE PREVENTION OF HPV 16, 18-ASSOCIATED CERVICAL CANCER. Biologics: Targets and Therapy, 2(1), 107-113; Krammer, F., Schinko, T., Palmberger, D., Tauer, C., Messner, P., & Grabherr, R. (2010). TRICHOPLUSIA NI CELLS (HIGH FIVE) ARE HIGHLY EFFICIENT FOR THE PRODUCTION OF INFLUENZA A VIRUS-LIKE PARTICLES: A COMPARISION OF TWO INSECT CELL LINES AS PRODUCTION PLATFORMS FOR INFLUENZA VACCINES. Molecular Biotechnology, 45 (3), 226-234.
Notes
Origin: this line is a clonal isolate of BTI-TN5B1-4 [High Five™] cell line; Unique properties: this cell line is used to produce the papilloma vaccine Cervarix™ using a baculovirus expression vector; the C-terminally truncated protein L1 of HPV-16 and HPV-18 are separately produced in this cell line using a recombinant baculovirus expression system.
Medium
Proprietary serum-free medium
Cell Culture Collection
GlaxoSmithKline
Status
Patents
European Patent No. EP2318042A1, Author: Dominique et al., Date: 20-August-2014
